| Challenger - Nottingham | 06/08 10:00 | 25 | [139] Brandon Nakashima v Vilella Martinez, Mario [183] | 6-3,6-2 | |
| French Open, Paris, France | 05/30 11:00 | 23 | [182] Vilella Martinez, Mario v Bautista-Agut, Roberto [11] | 4-6,4-6,2-6 | |
| French Open, Paris, France | 05/28 08:30 | 19 | [182] Vilella Martinez, Mario v Gojowczyk, Peter [134] | 4-6,6-3,6-2 | |
| French Open, Paris, France | 05/26 13:50 | 15 | [182] Vilella Martinez, Mario v Horansky, Filip [186] | 6-2,6-3 | |
| French Open, Paris, France | 05/25 13:55 | 14 | [110] Dennis Novak v Vilella Martinez, Mario [182] | 6-1,2-6,2-6 | |
| Challenger Prague | 05/04 14:10 | 25 | [176] Kacper Zuk v Vilella Martinez, Mario [178] | 7-6,2-6,7-5 | |
| ATP Marbella | 04/07 16:10 | 26 | [15] Carreno-Busta, Pablo v Vilella Martinez, Mario [188] | 7-6,6-3 | |
| ATP Marbella | 04/06 12:00 | 25 | [146] Bernabe Zapata Miralles v Vilella Martinez, Mario [188] | 2-6,3-6 | |
| ATP Marbella | 04/05 11:35 | 19 | [188] Vilella Martinez, Mario v Gomez-Herrera, Carlos [350] | 6-3,3-6,6-3 | |
| ATP Marbella | 04/04 13:50 | 14 | [131] Antoine Hoang v Vilella Martinez, Mario [196] | 2-6,4-6 | |
| Marbella, Spain | 04/03 12:35 | 28 | [99] Jaume Munar v Vilella Martinez, Mario [196] | 7-6,7-5 | |
| Marbella, Spain | 04/02 12:00 | 27 | [196] Vilella Martinez, Mario v Nikola Milojevic [148] | 6-3,6-4 | |
| Marbella, Spain | 04/01 10:00 | 26 | [126] Damir Dzumhur v Vilella Martinez, Mario [196] | 3-6,4-6 | |
| Marbella, Spain | 03/30 09:00 | 25 | [196] Vilella Martinez, Mario v Lorenzo Giustino [164] | 7-6,6-0 | |
| ATP - Miami | 03/23 14:00 | 19 | [196] Vilella Martinez, Mario v Thanasi Kokkinakis [243] | 5-7,1-6 | |
| ATP - Miami | 03/22 14:00 | 14 | [133] Stebe, Cedrik-Marcel v Vilella Martinez, Mario [196] | 6-7,3-6 | |
| ATP - Santiago | 03/07 18:40 | 15 | [236] Felipe M R Alves v Vilella Martinez, Mario [196] | 3-6,7-6,7-6 | |
| ATP - Santiago | 03/06 19:40 | 14 | [291] Lukas Klein v Vilella Martinez, Mario [196] | 4-6,2-6 | |
| ATP - Buenos Aires | 02/28 21:00 | 15 | [148] Sumit Nagal v Vilella Martinez, Mario [193] | 6-4,6-2 | |
| ATP - Buenos Aires | 02/27 13:00 | 14 | [193] Vilella Martinez, Mario v Barrios Vera, Marcelo Tomas [265] | 6-4,7-5 | |
| ATP - Cordoba | 02/20 15:20 | 14 | [390] Velotti, Agustin v Vilella Martinez, Mario [181] | 6-3,6-4 | |
| Open d'Australie | 02/09 06:15 | 23 | [199] Tomas Machac v Vilella Martinez, Mario [181] | Retired | |
| ATP Great Ocean Road Open | 02/04 23:30 | 26 | [52] Jordan Thompson v Vilella Martinez, Mario [188] | 6-4,6-4 | |
| ATP Great Ocean Road Open | 02/03 08:05 | 25 | [188] Vilella Martinez, Mario v Nikoloz Basilashvili [39] | 7-5,6-3 | |
| ATP Great Ocean Road Open | 02/02 06:05 | 24 | [101] Yannick Hanfmann v Vilella Martinez, Mario [188] | 6-7,4-6 | |
| Open d'Australie | 01/13 07:30 | 19 | [247] Tung-Lin Wu v Vilella Martinez, Mario [186] | 6-4,5-7,4-6 | |
| Open d'Australie | 01/12 07:30 | 15 | Vilella Martinez, Mario v Francisco Cerundolo | Walkover | |
| Open d'Australie | 01/10 10:40 | 60 | [162] Alessandro Giannessi v Vilella Martinez, Mario [186] | 1-6,3-6 | |
| Challenger Lima | 11/24 16:45 | 25 | [91] Federico Coria v Vilella Martinez, Mario [190] | 6-2,6-4 | |
| Challenger Guayaquil | 11/17 15:00 | 25 | [349] Jesper De Jong v Vilella Martinez, Mario [187] | 5-7,6-3,7-5 |