| Wimbledon, London, Great Britain | 06/22 10:00 | 19 | [120] Zdenek Kolar v Vilella Martinez, Mario [261] | Retired | |
| Wimbledon, London, Great Britain | 06/20 13:20 | 14 | [261] Vilella Martinez, Mario v Altug Celikbilek [181] | 6-2,7-6 | |
| French Open, Paris, France | 05/16 08:00 | 14 | [224] Vilella Martinez, Mario v Aleksandar Vukic [123] | 5-7,4-6 | |
| Challenger Murcia | 04/04 12:30 | 25 | Alexander Shevchenko v Vilella Martinez, Mario | Cancelled | |
| Marbella, Spain | 03/28 10:35 | 25 | [172] Vilella Martinez, Mario v Yannick Hanfmann [109] | 3-6,0-6 | |
| ATP - Buenos Aires | 02/05 19:10 | 14 | [169] Vilella Martinez, Mario v Yannick Hanfmann [120] | 6-4,6-7,3-6 | |
| Open d'Australie | 01/11 23:00 | 15 | [175] Vilella Martinez, Mario v Elias Ymer [169] | 6-4,4-6,6-7 | |
| Open d'Australie | 01/10 03:15 | 14 | [177] Vilella Martinez, Mario v Sela, Dudi [381] | 6-3,6-2 | |
| Alicante, Spain | 10/14 11:45 | 26 | [273] Nuno Borges v Vilella Martinez, Mario [173] | 3-6,6-3,6-1 | |
| Alicante, Spain | 10/12 11:40 | 25 | [452] Georgii Kravchenko v Vilella Martinez, Mario [173] | 3-6,2-6 | |
| Challenger Murcia | 09/27 15:15 | 25 | [257] Flavio Cobolli v Vilella Martinez, Mario [171] | 7-5,6-3 | |
| Challenger Quito | 09/16 15:00 | 26 | [169] Vilella Martinez, Mario v Gonzalo Lama [417] | 6-3,6-7,3-6 | |
| Challenger Quito | 09/14 16:50 | 25 | Vilella Martinez, Mario v Christian Langmo | 6-3,6-7,6-2 | |
| US Open, New York, USA | 08/25 19:40 | 14 | [131] Sugita, Yuichi v Vilella Martinez, Mario [162] | 3-6,6-3,6-2 | |
| Kitzbuhel, Austria | 07/28 18:30 | 26 | [14] Casper Ruud v Vilella Martinez, Mario [167] | 7-5,5-7,6-4 | |
| Kitzbuhel, Austria | 07/27 10:35 | 25 | Vilella Martinez, Mario v Lukas Neumayer | 6-7,7-5,6-4 | |
| Kitzbuhel, Austria | 07/25 10:00 | 19 | [130] Jozef Kovalik v Vilella Martinez, Mario [158] | 7-5,7-5 | |
| Kitzbuhel, Austria | 07/24 13:05 | 26 | [313] Lucas Miedler v Vilella Martinez, Mario [158] | 3-6,4-6 | |
| Challenger Tampere | 07/23 12:00 | 27 | [158] Vilella Martinez, Mario v Nicolas Kicker [384] | 6-7,0-6 | |
| Challenger Tampere | 07/22 09:00 | 26 | [158] Vilella Martinez, Mario v Pedro Cachin [278] | 7-5,6-4 | |
| Challenger Tampere | 07/20 12:40 | 25 | [158] Vilella Martinez, Mario v Joao Domingues [238] | 4-6,7-6,7-5 | |
| Challenger Todi | 07/18 18:30 | 29 | [151] Federico Gaio v Vilella Martinez, Mario [178] | 6-7,6-1,3-6 | |
| Challenger Todi | 07/17 16:35 | 28 | [409] Matheus P De Almeida v Vilella Martinez, Mario [178] | 6-7,6-3,1-6 | |
| Challenger Todi | 07/16 13:00 | 27 | [316] Giulio Zeppieri v Vilella Martinez, Mario [178] | 3-6,3-6 | |
| Challenger Todi | 07/15 13:00 | 26 | [368] Forti, Francesco v Vilella Martinez, Mario [178] | 3-6,1-6 | |
| Challenger Todi | 07/13 15:00 | 25 | [252] Tristan Lamasine v Vilella Martinez, Mario [178] | 2-6,6-7 | |
| Braunchsweig, Germany | 07/07 11:15 | 26 | [166] Daniel Altmaier v Vilella Martinez, Mario [179] | 6-3,6-2 | |
| Braunchsweig, Germany | 07/05 15:20 | 25 | [179] Vilella Martinez, Mario v Rudolf Molleker [311] | 3-6,6-4,6-3 | |
| Wimbledon, London, Great Britain | 06/22 13:25 | 14 | [418] Andrey Kuznetsov v Vilella Martinez, Mario [176] | 6-4,6-7,6-2 | |
| Challenger Nottingham Qual | 06/13 12:00 | 14 | [183] Vilella Martinez, Mario v Ebden, Matthew [230] | 3-6,3-6 |