| NCAAF | 09/19 00:00 | 1 | [82] Kentucky Wesleyan College Panthers v Lindenwood [150] | L | 34-56 | |
| NCAAF | 09/11 17:00 | 1 | Kentucky State v Kentucky Wesleyan College Panthers | W | 25-26 | |
| NCAAF | 09/02 23:00 | 1 | Kentucky Wesleyan College Panthers v Frostburg State Bobcats | L | 13-20 | |
| NCAAF | 11/16 19:00 | 1 |
Kentucky Wesleyan College Panthers
v
Alderson Broaddus Battlers
|
W | 41-30 | |
| NCAAF | 11/09 18:00 | 1 | Frostburg State Bobcats v Kentucky Wesleyan College Panthers | L | 35-25 | |
| NCAAF | 11/02 23:30 | 1 | Walsh v Kentucky Wesleyan College Panthers | L | 27-24 | |
| NCAAF | 10/26 18:30 | 1 | Hillsdale Chargers v Kentucky Wesleyan College Panthers | L | 41-14 | |
| NCAAF | 10/19 18:00 | 1 | Kentucky Wesleyan College Panthers v Ohio Dominican Panthers | L | 7-47 | |
| NCAAF | 10/12 18:00 | 1 | Kentucky Wesleyan College Panthers v Tiffin Dragons | L | 6-59 | |
| NCAAF | 10/05 23:00 | 1 | Findlay Oilers v Kentucky Wesleyan College Panthers | L | 38-13 | |
| NCAAF | 09/28 18:00 | 1 | Lake Erie Storm v Kentucky Wesleyan College Panthers | L | 49-42 | |
| NCAAF | 09/21 20:00 | 1 | Kentucky Wesleyan College Panthers v Southwest Baptist | L | 13-20 | |
| NCAAF | 09/14 18:00 | 1 | Kentucky Wesleyan College Panthers v Quincy Hawks | L | 16-34 | |
| NCAAF | 11/10 17:00 | 1 |
Alderson Broaddus Battlers
v
Kentucky Wesleyan College Panthers
|
L | 51-7 | |
| NCAAF | 11/03 16:00 | 1 | Ohio Dominican Panthers v Kentucky Wesleyan College Panthers | L | 65-7 | |
| NCAAF | 10/27 17:00 | 1 | Hillsdale Chargers v Kentucky Wesleyan College Panthers | L | 34-0 | |
| NCAAF | 10/20 18:00 | 1 | Kentucky Wesleyan College Panthers v Lake Erie Storm | W | 46-6 | |
| NCAAF | 10/13 20:00 | 1 | Tiffin Dragons v Kentucky Wesleyan College Panthers | L | 43-17 | |
| NCAAF | 09/29 18:00 | 1 | Kentucky Wesleyan College Panthers v Walsh | L | 17-23 | |
| NCAAF | 09/22 18:00 | 1 | Kentucky Wesleyan College Panthers v Malone University Pioneers | W | 44-38 | |
| NCAAF | 09/15 23:00 | 1 | Kentucky Wesleyan College Panthers v Kentucky State | W | 19-13 | |
| NCAAF | 09/08 18:00 | 1 | Quincy Hawks v Kentucky Wesleyan College Panthers | L | 31-24 | |
| NCAAF | 09/01 18:00 | 1 | Kentucky Wesleyan College Panthers v Findlay Oilers | L | 19-69 | |
| NCAAF | 08/31 23:00 | 1 | Murray State v Kentucky Wesleyan College Panthers | L | 67-7 |