| WTA Concord | 08/03 18:55 | 25 | [178] Tatjana Maria v Varvara Lepchenko [126] | 0-6,3-6 | |
| WTA - Charleston | 08/01 14:00 | 29 | [229] Jamie Loeb v Varvara Lepchenko [152] | 6-7,6-4,4-6 | |
| WTA - Charleston | 07/31 14:00 | 28 | [152] Varvara Lepchenko v Lauren Davis [94] | 7-5,6-3 | |
| WTA - Charleston | 07/30 16:45 | 27 | [285] Hanna Chang v Varvara Lepchenko [152] | 1-6,1-6 | |
| WTA - Charleston | 07/28 21:30 | 26 | Kinard, Tori v Varvara Lepchenko | 2-6,3-6 | |
| WTA - Charleston | 07/27 14:00 | 25 | [297] Carol Zhao v Varvara Lepchenko [152] | 1-6,5-7 | |
| WTA Gdynia | 07/22 09:00 | 26 | [208] Ekaterine Gorgodze v Varvara Lepchenko [154] | 7-6,6-2 | |
| WTA Gdynia | 07/20 09:00 | 25 | [187] Marina Melnikova v Varvara Lepchenko [154] | 6-4,6-7,3-6 | |
| WTA Budapest | 07/13 09:00 | 25 | [155] Varvara Lepchenko v Ana Bogdan [98] | 4-6,5-7 | |
| WTA Bastad | 07/06 08:30 | 25 | [148] Nuria Parrizas-Diaz v Varvara Lepchenko [155] | 6-4,6-2 | |
| Wimbledon Women | 06/24 14:30 | 19 | [119] Greet Minnen v Varvara Lepchenko [156] | 6-2,6-2 | |
| Wimbledon Women | 06/23 16:40 | 15 | [156] Varvara Lepchenko v Harmony Tan [132] | 6-4,3-6,6-2 | |
| Wimbledon Women | 06/22 18:15 | 14 | [182] Ankita Raina v Varvara Lepchenko [156] | 3-6,6-7 | |
| WTA Berlin | 06/12 11:10 | 14 | [171] Varvara Lepchenko v Anna-Lena Friedsam [114] | Retired | |
| French Open Women | 06/03 09:00 | 24 | [171] Varvara Lepchenko v Muchova, Karolina [19] | 3-6,4-6 | |
| French Open Women | 06/01 15:25 | 23 | [171] Varvara Lepchenko v Shuai Zhang [46] | 6-3,6-3 | |
| French Open Women | 05/27 11:05 | 19 | [114] Anna-Lena Friedsam v Varvara Lepchenko [170] | 1-6,3-6 | |
| French Open Women | 05/26 10:55 | 15 | [197] Mona Barthel v Varvara Lepchenko [170] | 1-6,5-7 | |
| French Open Women | 05/24 16:10 | 14 | [170] Varvara Lepchenko v Kamilla Rakhimova [128] | 6-4,1-6,7-5 | |
| ITF - W100 Bonita Springs | 05/13 19:20 | 26 | [171] Varvara Lepchenko v Irina Fetecau [310] | Retired | |
| ITF - W100 Bonita Springs | 05/12 20:30 | 25 | [212] Whitney Osuigwe v Varvara Lepchenko [171] | 4-6,3-6 | |
| WTA Guadalajara | 03/07 18:00 | 19 | [133] Elisabetta Cocciaretto v Varvara Lepchenko [176] | 7-6,6-4 | |
| WTA Guadalajara | 03/06 18:20 | 14 | [176] Varvara Lepchenko v Kucova, Kristina [149] | 7-6,6-4 | |
| ITF W25 Boca Raton | 02/28 14:45 | 29 | [177] Varvara Lepchenko v Claire Liu [219] | 3-6,6-4,6-0 | |
| ITF W25 Boca Raton | 02/27 17:35 | 28 | [242] Hailey Baptiste v Varvara Lepchenko [177] | 3-6,7-6,2-6 | |
| ITF W25 Boca Raton | 02/26 17:50 | 27 | [265] Katherine Sebov v Varvara Lepchenko [177] | 4-6,6-4,5-7 | |
| ITF W25 Boca Raton | 02/25 16:00 | 26 | Ashlyn Krueger v Varvara Lepchenko | 3-6,4-6 | |
| ITF W25 Boca Raton | 02/24 15:00 | 25 | [194] Rebecca Sramkova v Varvara Lepchenko [177] | 0-6,7-6,3-6 | |
| WTA Melbourne | 02/15 05:00 | 25 | [182] Varvara Lepchenko v Danielle Collins [40] | 7-6,1-6,3-6 | |
| WTA Melbourne | 02/14 02:10 | 24 | [182] Varvara Lepchenko v Nao Hibino [76] | Retired |