| WTA Guangzhou | 09/14 07:05 | 45 | [121] Varvara Lepchenko v Magdalena Frech [207] | Retired | |
| Hiroshima, Japon | 09/09 06:45 | 25 | [118] Varvara Lepchenko v Veronika Kudermetova [51] | 4-6,2-6 | |
| New Haven, USA | 09/05 15:50 | 26 | [118] Varvara Lepchenko v Lauren Davis [73] | 6-4,0-6,4-6 | |
| New Haven, USA | 09/04 18:05 | 25 | [118] Varvara Lepchenko v Arruabarrena, L. [155] | 6-1,4-6,6-4 | |
| US Open Women | 08/26 20:05 | 23 | [167] Peng, Shuai v Varvara Lepchenko [118] | 6-2,7-6 | |
| US Open Women | 08/23 19:55 | 46 | [118] Varvara Lepchenko v Timea Babos [112] | 6-7,4-6 | |
| US Open Women | 08/22 15:00 | 45 | [118] Varvara Lepchenko v Garcia Perez, Georgina [223] | 6-4,7-6 | |
| US Open Women | 08/20 22:20 | 44 | [118] Varvara Lepchenko v Zhang, Kai Lin [219] | 4-6,6-1,6-4 | |
| Vancouver, Simples W-ITF-CAN-02A | 08/13 18:40 | 25 | [277] Fernandez, Leylah Annie v Varvara Lepchenko [116] | 6-3,7-6 | |
| WTA Toronto | 08/04 14:00 | 45 | [37] Alison Riske v Varvara Lepchenko [117] | 6-4,6-4 | |
| WTA Toronto | 08/03 14:00 | 44 | [274] Hradecka, Lucie v Varvara Lepchenko [117] | 3-6,4-6 | |
| WTA Bucharest | 07/16 16:00 | 25 | [117] Varvara Lepchenko v Di Giuseppe, Martina [211] | 6-3,1-6,6-7 | |
| ITF W100 Contrexeville | 07/11 09:30 | 26 | [124] Varvara Lepchenko v Tessah Andrianjafitrimo [334] | 6-1,1-6,0-6 | |
| ITF W100 Contrexeville | 07/09 11:05 | 25 | [124] Varvara Lepchenko v Lemoine, Quirine [244] | 6-2,6-7,6-4 | |
| Wimbledon Women | 06/26 14:35 | 45 | [123] Varvara Lepchenko v Pattinama Kerkh., L. [203] | 6-4,1-6,2-6 | |
| Wimbledon Women | 06/25 13:40 | 44 | [123] Varvara Lepchenko v Sofya Zhuk [158] | 7-6,2-6,6-0 | |
| WTA Mallorca | 06/18 09:00 | 25 | [123] Varvara Lepchenko v Anastasija Sevastova [12] | 3-6,6-7 | |
| WTA Mallorca | 06/17 10:15 | 64 | [173] Nara, Kurumi v Varvara Lepchenko [123] | 4-6,6-2,0-6 | |
| WTA Mallorca | 06/16 09:30 | 45 | [165] Irina Bara v Varvara Lepchenko [127] | 6-2,1-6,2-6 | |
| WTA Hertogenbosch | 06/10 10:25 | 25 | [127] Varvara Lepchenko v Elena Rybakina [134] | 1-6,2-6 | |
| WTA Hertogenbosch | 06/09 13:10 | 64 | [129] Varvara Lepchenko v Anna Kalinskaya [146] | 6-2,7-6 | |
| WTA Hertogenbosch | 06/08 15:15 | 45 | Varvara Lepchenko v Indy De Vroome | 6-1,6-4 | |
| French Open Women | 05/27 11:35 | 23 | [50] Shuai Zhang v Varvara Lepchenko [129] | 6-1,6-1 | |
| French Open Women | 05/24 11:15 | 46 | [193] Valentini Grammatikopoulou v Varvara Lepchenko [130] | 2-6,2-6 | |
| French Open Women | 05/23 09:30 | 45 | Oprandi, Romina v Varvara Lepchenko | 1-6,1-6 | |
| French Open Women | 05/21 14:30 | 44 | [148] Anna Kalinskaya v Varvara Lepchenko [130] | 6-7,4-6 | |
| Cagnes-Sur-Mer, Simples W-ITF-FRA-12A | 05/10 08:30 | 27 | [137] Timea Babos v Varvara Lepchenko [131] | 6-4,6-3 | |
| Cagnes-Sur-Mer, Simples W-ITF-FRA-12A | 05/08 10:50 | 26 | [131] Varvara Lepchenko v Varvara Gracheva [328] | 7-5,6-4 | |
| Cagnes-Sur-Mer, Simples W-ITF-FRA-12A | 05/07 10:10 | 25 | [169] Viktoriya Tomova v Varvara Lepchenko [131] | 0-6,4-6 | |
| WTA Rabat | 05/01 10:00 | 26 | [149] Varvara Lepchenko v Alison Van Uytvanck [52] | 4-6,0-6 |