Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Nick Hill
| NCAAF | 2022/09/10 23:00 | SE Missouri State v Southern Illinois | L | 34-31 |
| NCAAF | 2021/09/02 23:30 | Southern Illinois v SE Missouri State | W | 47-21 |
| NCAAF | 2020/10/30 23:00 | SE Missouri State v Southern Illinois | W | 17-20 |
| NCAAF | 2019/08/29 23:30 | Southern Illinois v SE Missouri State | L | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri State v Southern Illinois | L | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri State v Southern Illinois | W | 17-35 |
| NCAAF | 2023/09/09 19:30 | Southern Illinois v Northern Illinois | W | 14-11 |
| NCAAF | 2023/09/02 23:00 | Austin Peay v Southern Illinois | W | 23-49 |
| NCAAF | 2022/11/19 17:00 | Southern Illinois v Youngstown State | L | 21-28 |
| NCAAF | 2022/11/12 19:00 | DAKOTA DU NORD ETAT DU BISON v Southern Illinois | L | 21-18 |
| NCAAF | 2022/10/29 19:00 | Northern Iowa v Southern Illinois | L | 37-36 |
| NCAAF | 2022/10/22 19:00 | Southern Illinois v South Dakota | L | 24-27 |
| NCAAF | 2022/10/15 19:00 | Western Illinois v Southern Illinois | W | 7-30 |
| NCAAF | 2022/10/08 19:00 | Southern Illinois v Missouri State | W | 38-21 |
| NCAAF | 2023/09/09 23:00 | Lindenwood v SE Missouri State | W | 7-45 |
| NCAAF | 2023/09/02 23:00 | SE Missouri State v Kansas State | L | 0-45 |
| NCAAF | 2022/11/27 03:00 | SE Missouri State v Montana | L | 24-34 |
| NCAAF | 2022/11/19 19:00 | Murray State v SE Missouri State | W | 22-52 |
| NCAAF | 2022/11/12 20:00 | SE Missouri State v Eastern Illinois | W | 31-7 |
| NCAAF | 2022/11/05 22:00 | SE Missouri State v Tennessee State | W | 42-0 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri State | L | 28-23 |
| NCAAF | 2022/10/22 18:00 | SE Missouri State v Northwestern State | W | 51-16 |