Stadium: Ace W. Mumford Stadium Round: 1
Home Manager: Eric Dooley Away Manager: Bubba McDowell
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View A&M | L | 45-13 |
| NCAAF | 2021/10/23 23:00 | Prairie View A&M v Southern | W | 48-21 |
| NCAAF | 2019/10/12 23:00 | Prairie View A&M v Southern | L | 28-34 |
| NCAAF | 2018/10/13 22:00 | Southern v Prairie View A&M | L | 38-0 |
| NCAAF | 2017/11/04 21:00 | Southern v Prairie View A&M | L | 37-31 |
| NCAAF | 2023/11/04 19:00 | Arkansas-Pine Bluff v Prairie View A&M | W | 14-38 |
| NCAAF | 2023/10/28 20:00 | Prairie View A&M v Florida A&M | L | 7-45 |
| NCAAF | 2023/10/14 23:00 | Prairie View A&M v Houston Baptist | L | 0-30 |
| NCAAF | 2023/10/07 23:00 | Mississippi Valley v Prairie View A&M | W | 12-31 |
| NCAAF | 2023/09/30 23:00 | Grambling State v Prairie View A&M | L | 35-20 |
| NCAAF | 2023/09/23 23:00 | Prairie View A&M v Alcorn State | W | 23-20 |
| NCAAF | 2023/09/16 23:00 | Prairie View A&M v SMU | L | 0-69 |
| NCAAF | 2023/09/09 23:00 | Abilene Christian v Prairie View A&M | L | 45-16 |
| NCAAF | 2023/11/04 19:00 | Southern v Alcorn State | L | 21-44 |
| NCAAF | 2023/10/28 21:00 | Texas Southern v Southern | W | 17-23 |
| NCAAF | 2023/10/21 20:00 | Southern v Bethune-Cookman | W | 28-18 |
| NCAAF | 2023/10/14 21:00 | Southern v Lincoln Oaklanders | W | 45-18 |
| NCAAF | 2023/10/07 23:00 | Florida A&M v Southern | L | 26-19 |
| NCAAF | 2023/09/30 21:00 | Southern v Arkansas-Pine Bluff | W | 27-0 |
| NCAAF | 2023/09/16 23:00 | Alabama A&M v Southern | W | 10-20 |
| NCAAF | 2023/09/09 23:00 | Jackson State v Southern | L | 27-14 |