Stadium: Marion Bowman Activities Center
| NCAAB | 2023/01/28 21:00 | Palm Beach Atlantic Sailfish v Saint Leo Lions | L | 75-70 |
| NCAAB | 2023/01/26 00:30 | Florida Tech v Saint Leo Lions | W | 72-92 |
| NCAAB | 2023/01/21 23:00 | Saint Leo Lions v Barry Buccaneers | W | 97-56 |
| NCAAB | 2023/01/19 00:30 | Saint Leo Lions v Rollins Tars | L | 95-98 |
| NCAAB | 2023/01/14 21:00 | Nova Southeastern v Saint Leo Lions | L | 106-84 |
| NCAAB | 2023/01/12 00:30 | Florida Southern v Saint Leo Lions | W | 64-71 |
| NCAAB | 2023/01/07 23:00 | Saint Leo Lions v Lynn Fighting Knights | W | 100-89 |
| NCAAB | 2023/01/05 00:30 | Saint Leo Lions v Tampa Spartans | W | 77-71 |
| NCAAB | 2023/01/13 00:00 | North Greenville Crusaders v Paine Lions | L | 85-79 |
| NCAAB | 2023/01/11 00:00 | Edward Waters Tigers v Paine Lions | L | 93-86 |
| NCAAB | 2022/12/31 21:00 | Shaw Bears v Paine Lions | L | 93-92 |
| NCAAB | 2022/12/12 22:00 | Elizabeth City v Paine Lions | L | 85-74 |
| NCAAB | 2022/12/06 00:30 | Claflin Panthers v Paine Lions | L | 86-84 |
| NCAAB | 2022/12/03 20:00 | Queens Royals v Paine Lions | L | 89-60 |
| NCAAB | 2022/11/19 00:30 | Fort Valley State Wildcats v Paine Lions | L | 59-51 |
| NCAAB | 2020/03/06 00:45 | Paine Lions v Morehouse Maroon Tigers | L | 54-72 |