Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2019/10/05 18:00 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 63-6 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2022/09/17 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 20-40 |
| NCAAF | 2022/09/10 23:00 | North Alabama Lions v Virginia Wise Highland Cavaliers | L | 49-17 |
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | W | 41-9 |
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 24-36 |
| NCAAF | 2021/11/06 17:00 | Catawba v Virginia Wise Highland Cavaliers | W | 7-30 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2022/09/24 22:00 | Lenoir Rhyne Bears v Carson-Newman Eagles | W | 34-13 |
| NCAAF | 2022/09/17 20:00 | Erskine Flying Fleet v Lenoir Rhyne Bears | W | 20-42 |
| NCAAF | 2022/09/10 17:00 | Lenoir Rhyne Bears v Ferris State Bulldogs | L | 5-27 |
| NCAAF | 2022/09/03 22:00 | Lenoir Rhyne Bears v Virginia State Trojans | W | 38-19 |
| NCAAF | 2021/11/20 18:00 | Bowie State Bulldogs v Lenoir Rhyne Bears | L | 31-10 |
| NCAAF | 2021/11/13 18:00 | Lenoir Rhyne Bears v Catawba | W | 56-3 |
| NCAAF | 2021/11/06 20:00 | Barton Bulldogs v Lenoir Rhyne Bears | W | 20-56 |
| NCAAF | 2021/10/30 22:00 | Wingate Bulldogs v Lenoir Rhyne Bears | W | 6-31 |