Stadium: Lewis Field Stadium Round: 1
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | W | 21-42 |
| NCAAF | 2019/09/29 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 44-3 |
| NCAAF | 2018/09/22 23:00 | Missouri Southern Lions v Fort Hays State University Tigers | W | 20-55 |
| NCAAF | 2022/09/17 23:00 | Blue Tigers v Fort Hays State University Tigers | W | 14-51 |
| NCAAF | 2022/09/09 00:00 | Fort Hays State University Tigers v Missouri Western Griffons | L | 19-35 |
| NCAAF | 2022/09/02 00:00 | Northwest Missouri v Fort Hays State University Tigers | L | 33-19 |
| NCAAF | 2021/11/13 19:00 | Fort Hays State University Tigers v Pittsburg State Gorillas | L | 24-34 |
| NCAAF | 2021/10/30 18:00 | Fort Hays State University Tigers v Emporia State | L | 12-15 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | W | 17-21 |
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | L | 14-24 |
| NCAAF | 2021/10/09 18:00 | Washburn Ichabods Football v Fort Hays State University Tigers | L | 23-20 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | W | 40-21 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |
| NCAAF | 2021/11/13 19:00 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v Northwest Missouri | L | 7-49 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 |