Stadium: O'Shaughnessy Stadium Round: 1
Home Manager: Glenn Caruso Away Manager: Roger Hughes
| NCAAF | 2022/11/05 17:00 | Stetson Hatters v Davidson Wildcats | L | 48-56 |
| NCAAF | 2022/10/29 17:00 | Drake v Stetson Hatters | L | 24-17 |
| NCAAF | 2022/10/22 17:00 | Stetson Hatters v Dayton | L | 20-23 |
| NCAAF | 2022/10/08 17:00 | Marist Red Foxes v Stetson Hatters | L | 45-31 |
| NCAAF | 2022/09/24 17:00 | Morehead State v Stetson Hatters | W | 26-38 |
| NCAAF | 2022/09/17 17:00 | Princeton Tigers v Stetson Hatters | L | 39-14 |
| NCAAF | 2022/09/10 22:00 | Stetson Hatters v Louisiana College Wildcats | W | 45-14 |
| NCAAF | 2022/09/03 22:00 | Concordia (Mi) Cardinals v Stetson Hatters | W | 14-24 |
| NCAAF | 2022/11/05 18:00 | Saint Thomas v Valparaiso Crusaders | W | 34-7 |
| NCAAF | 2022/10/29 17:00 | San Diego v Saint Thomas | W | 42-49 |
| NCAAF | 2022/10/22 17:00 | Saint Thomas v Presbyterian | W | 46-17 |
| NCAAF | 2022/10/15 18:00 | Drake v Saint Thomas | W | 14-26 |
| NCAAF | 2022/10/08 18:00 | Davidson Wildcats v Saint Thomas | W | 16-27 |
| NCAAF | 2022/10/01 16:00 | Saint Thomas v Marist Red Foxes | W | 38-24 |
| NCAAF | 2022/09/24 18:00 | Saint Thomas v Lincoln Oaklanders | W | 43-6 |
| NCAAF | 2022/09/10 18:00 | Saint Thomas v Michigan Tech | W | 32-6 |