Stadium: O'Kelly-Riddick Stadium Round: 1
Home Manager: Trei Oliver Away Manager:
| NCAAF | 2022/09/03 23:30 | North Carolina A&T v N.C. Central | W | 13-28 |
| NCAAF | 2021/11/20 19:00 | Delaware State v N.C. Central | W | 28-34 |
| NCAAF | 2021/11/13 18:00 | N.C. Central v Howard | W | 45-27 |
| NCAAF | 2021/11/06 18:00 | Norfolk State v N.C. Central | W | 36-38 |
| NCAAF | 2021/10/30 18:00 | South Carolina State v N.C. Central | L | 27-24 |
| NCAAF | 2021/10/23 17:00 | N.C. Central v Morgan State | W | 28-17 |
| NCAAF | 2021/10/09 18:00 | Tennessee Tech v N.C. Central | L | 27-16 |
| NCAAF | 2021/10/02 20:00 | N.C. Central v Mississippi Valley | L | 16-17 |
| NCAAF | 2022/09/04 20:00 | Winston-Salem State v Central State (Oh) Marauders | L | 21-41 |
| NCAAF | 2021/11/06 18:00 | Fayetteville State Broncos v Winston-Salem State | L | 10-3 |
| NCAAF | 2021/10/30 17:00 | Shaw Bears v Winston-Salem State | L | 38-14 |
| NCAAF | 2021/10/23 17:00 | Winston-Salem State v Livingstone | W | 21-0 |
| NCAAF | 2021/10/16 17:30 | Winston-Salem State v St Augustines Falcons | W | 41-0 |
| NCAAF | 2021/10/09 17:00 | Johnson C. Smith v Winston-Salem State | W | 12-26 |
| NCAAF | 2021/10/02 22:00 | Chowan University v Winston-Salem State | L | 73-7 |
| NCAAF | 2021/09/25 17:30 | Winston-Salem State v Elizabeth City State Vikings | L | 14-19 |