Stadium: Torero Stadium Round: 1
Home Manager: Dale Lindsey Away Manager: Steve Englehart
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | L | 69-28 |
| NCAAF | 2021/03/27 15:00 | San Diego v Presbyterian | L | 24-21 |
| NCAAF | 2022/10/08 16:00 | Valparaiso Crusaders v Presbyterian | L | 41-21 |
| NCAAF | 2022/10/01 17:00 | Presbyterian v Morehead State | L | 10-14 |
| NCAAF | 2022/09/24 23:00 | Davidson Wildcats v Presbyterian | L | 56-24 |
| NCAAF | 2022/09/17 19:30 | Presbyterian v Western Carolina | L | 21-77 |
| NCAAF | 2022/09/10 17:00 | Presbyterian v Virginia Lynchburg | W | 21-13 |
| NCAAF | 2022/09/03 23:00 | Presbyterian v Austin Peay | L | 0-63 |
| NCAAF | 2021/11/20 19:00 | Presbyterian v Saint Thomas | L | 15-54 |
| NCAAF | 2021/11/13 18:00 | Marist Red Foxes v Presbyterian | L | 57-32 |
| NCAAF | 2022/10/08 18:00 | San Diego v Drake | W | 22-10 |
| NCAAF | 2022/09/24 17:00 | San Diego v Valparaiso Crusaders | L | 21-28 |
| NCAAF | 2022/09/18 02:00 | San Diego v UC Davis | L | 13-43 |
| NCAAF | 2022/09/10 21:00 | San Diego v Cal Poly | L | 27-28 |
| NCAAF | 2022/09/04 01:00 | La Verne Leopards v San Diego | W | 0-58 |
| NCAAF | 2021/11/20 18:00 | San Diego v Stetson Hatters | W | 41-16 |
| NCAAF | 2021/11/06 20:00 | Morehead State v San Diego | W | 3-10 |
| NCAAF | 2021/10/30 20:00 | Valparaiso Crusaders v San Diego | W | 14-21 |