Stadium: Cameron Indoor stadium
Home Manager: Mike Krzyzewski Away Manager: Tim Craft
| NCAAB | 2021/11/13 20:00 | Gardner Webb v Arkansas | L | 69-86 |
| NCAAB | 2021/11/11 03:00 | Gardner Webb v UNLV | L | 58-64 |
| NCAAB | 2021/03/02 00:00 | Gardner Webb v Campbell | L | 57-63 |
| NCAAB | 2021/02/22 23:00 | Gardner Webb v USC Upstate | W | 69-58 |
| NCAAB | 2021/02/18 23:00 | Gardner Webb v Radford | W | 77-49 |
| NCAAB | 2021/02/17 23:00 | Gardner Webb v Radford | W | 69-57 |
| NCAAB | 2021/02/12 21:00 | Gardner Webb v Longwood | L | 71-78 |
| NCAAB | 2021/02/11 21:00 | Gardner Webb v Longwood | L | 54-57 |
| NCAAB | 2021/11/14 01:00 | Campbell v Duke | W | 56-67 |
| NCAAB | 2021/11/13 00:00 | Army v Duke | W | 56-82 |
| NCAAB | 2021/11/10 02:30 | Kentucky v Duke | W | 71-79 |
| NCAAB | 2021/03/10 23:30 | Duke v Louisville | W | 70-56 |
| NCAAB | 2021/03/09 21:30 | Boston College v Duke | W | 51-86 |
| NCAAB | 2021/03/06 23:00 | Duke v North Carolina | L | 73-91 |
| NCAAB | 2021/03/03 01:00 | Duke v Georgia Tech | L | 77-81 |
| NCAAB | 2021/02/27 23:00 | Louisville v Duke | L | 80-73 |