Stadium: John O'Quinn Field at TDECU Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Broderick Fobbs
| NCAAF | 2014/09/07 00:00 | Houston Cougars v Grambling State | L | 47-0 |
| NCAAF | 2006/09/16 12:00 | Houston Cougars v Grambling State | L | 42-22 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Miss | L | 0-37 |
| NCAAF | 2021/09/05 20:00 | Grambling State v Tennessee State | W | 16-10 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | L | 7-49 |
| NCAAF | 2021/03/20 17:00 | Arkansas-Pine Bluff v Grambling State | L | 48-21 |
| NCAAF | 2021/03/13 21:00 | Prairie View A&M v Grambling State | L | 17-10 |
| NCAAF | 2021/03/06 18:00 | Jackson State v Grambling State | L | 33-28 |
| NCAAF | 2019/11/30 22:00 | Southern v Grambling State | L | 30-28 |
| NCAAF | 2019/11/16 19:00 | Grambling State v Mississippi Valley | W | 40-0 |
| NCAAF | 2021/09/11 22:30 | Houston Cougars v Rice | W | 44-7 |
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston Cougars | L | 38-21 |
| NCAAF | 2020/12/24 20:30 | Hawaii v Houston Cougars | L | 28-14 |
| NCAAF | 2020/12/12 20:45 | Houston Cougars v Memphis | L | 27-30 |
| NCAAF | 2020/11/14 20:30 | FLORIDE DU SUD v Houston Cougars | W | 21-56 |
| NCAAF | 2020/11/07 20:30 | Houston Cougars v Cincinnati | L | 10-38 |
| NCAAF | 2020/10/31 18:00 | UCF v Houston Cougars | L | 44-21 |
| NCAAF | 2020/10/24 19:30 | Houston Cougars v Navy | W | 37-21 |