Stadium: Spec Martin Stadium Round: 1
Home Manager: Roger Hughes Away Manager: Dale Lindsey
| NCAAF | 2021/04/10 20:00 | Stetson Hatters v San Diego | W | 10-34 |
| NCAAF | 2019/11/09 17:00 | San Diego v Stetson Hatters | W | 51-7 |
| NCAAF | 2018/09/29 21:00 | Stetson Hatters v San Diego | W | 10-49 |
| NCAAF | 2017/10/28 17:00 | Stetson Hatters v San Diego | W | 7-48 |
| NCAAF | 2021/11/06 20:00 | Morehead State v San Diego | W | 3-10 |
| NCAAF | 2021/10/30 20:00 | Valparaiso Crusaders v San Diego | W | 14-21 |
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | W | 69-28 |
| NCAAF | 2021/10/16 21:00 | Drake v San Diego | W | 10-13 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler Bulldogs | W | 52-21 |
| NCAAF | 2021/10/02 20:00 | Saint Thomas v San Diego | W | 24-27 |
| NCAAF | 2021/09/25 16:00 | San Diego v Davidson Wildcats | L | 16-28 |
| NCAAF | 2021/09/18 19:00 | San Diego v Montana State | L | 10-52 |
| NCAAF | 2021/11/13 18:00 | Stetson Hatters v Morehead State | L | 35-36 |
| NCAAF | 2021/11/06 17:00 | Dayton v Stetson Hatters | L | 41-13 |
| NCAAF | 2021/10/30 17:00 | Stetson Hatters v Presbyterian | W | 56-14 |
| NCAAF | 2021/10/16 17:00 | Saint Thomas v Stetson Hatters | L | 38-7 |
| NCAAF | 2021/10/09 16:00 | Stetson Hatters v Marist Red Foxes | L | 3-34 |
| NCAAF | 2021/10/02 17:00 | Davidson Wildcats v Stetson Hatters | L | 35-28 |
| NCAAF | 2021/09/25 17:00 | Stetson Hatters v Princeton Tigers | L | 0-63 |
| NCAAF | 2021/09/11 22:00 | Stetson Hatters v Ave Maria Gyrenes | W | 49-16 |