Stadium: Torero Stadium Round: 1
Home Manager: Dale Lindsey Away Manager: Rob Tenyer
| NCAAF | 2019/11/16 22:00 | Morehead State v San Diego | L | 20-52 |
| NCAAF | 2018/10/06 16:00 | San Diego v Morehead State | L | 51-34 |
| NCAAF | 2017/10/14 21:00 | San Diego v Morehead State | L | 56-27 |
| NCAAF | 2021/10/30 18:00 | Davidson Wildcats v Morehead State | L | 29-22 |
| NCAAF | 2021/10/23 16:00 | Morehead State v Marist Red Foxes | W | 27-24 |
| NCAAF | 2021/10/16 19:00 | Butler Bulldogs v Morehead State | W | 8-31 |
| NCAAF | 2021/10/09 17:00 | Morehead State v Presbyterian | W | 38-30 |
| NCAAF | 2021/10/02 18:00 | Dayton v Morehead State | W | 38-45 |
| NCAAF | 2021/09/18 19:00 | Morehead State v Austin Peay | L | 35-59 |
| NCAAF | 2021/09/04 22:00 | Morehead State v James Madison | L | 10-68 |
| NCAAF | 2021/04/17 20:00 | Butler Bulldogs v Morehead State | W | 18-28 |
| NCAAF | 2021/10/30 20:00 | Valparaiso Crusaders v San Diego | W | 14-21 |
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | W | 69-28 |
| NCAAF | 2021/10/16 21:00 | Drake v San Diego | W | 10-13 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler Bulldogs | W | 52-21 |
| NCAAF | 2021/10/02 20:00 | Saint Thomas v San Diego | W | 24-27 |
| NCAAF | 2021/09/25 16:00 | San Diego v Davidson Wildcats | L | 16-28 |
| NCAAF | 2021/09/18 19:00 | San Diego v Montana State | L | 10-52 |
| NCAAF | 2021/09/11 20:00 | UC Davis v San Diego | L | 53-7 |