| NCAAF | 2021/03/13 19:00 | San Diego v Drake | L | 13-10 |
| NCAAF | 2019/11/02 21:00 | Drake v San Diego | L | 7-49 |
| NCAAF FCS | 2018/11/03 18:00 | San Diego v Drake | L | 27-10 |
| NCAAF | 2017/11/04 21:00 | San Diego v Drake | L | 45-15 |
| NCAAF | 2021/10/09 17:00 | Dayton v Drake | L | 28-10 |
| NCAAF | 2021/10/02 16:00 | Drake v Butler Bulldogs | W | 6-3 |
| NCAAF | 2021/09/25 17:00 | Valparaiso Crusaders v Drake | L | 24-21 |
| NCAAF | 2021/09/18 21:00 | Drake v North Dakota | L | 0-38 |
| NCAAF | 2021/09/12 00:00 | Drake v Montana State | L | 7-45 |
| NCAAF | 2021/09/02 23:00 | Drake v W. Virginia Bobcats | W | 45-3 |
| NCAAF | 2021/04/17 18:00 | Presbyterian v Drake | L | 28-24 |
| NCAAF | 2021/04/10 16:00 | Drake v Butler Bulldogs | W | 33-7 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler Bulldogs | W | 52-21 |
| NCAAF | 2021/10/02 20:00 | Saint Thomas v San Diego | W | 24-27 |
| NCAAF | 2021/09/25 16:00 | San Diego v Davidson Wildcats | L | 16-28 |
| NCAAF | 2021/09/18 19:00 | San Diego v Montana State | L | 10-52 |
| NCAAF | 2021/09/11 20:00 | UC Davis v San Diego | L | 53-7 |
| NCAAF | 2021/09/04 20:00 | Cal Poly v San Diego | L | 28-17 |
| NCAAF | 2021/04/17 17:00 | San Diego v Valparaiso Crusaders | L | 19-20 |
| NCAAF | 2021/04/10 20:00 | Stetson Hatters v San Diego | W | 10-34 |