[14] Southern Illinois 23-31 Kansas State [51] 2021-09-11 23:00
Stadium: Bill Snyder Football Stadium Round: 1
Home Manager: Chris Klieman Away Manager: Nick Hill
Home History
| NCAAF | 2021/09/02 23:30 | Southern Illinois v SE Missouri State | W | 47-21 |
| NCAAF | 2021/05/03 01:00 | Southern Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | Southern Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v Southern Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | Southern Illinois v Missouri State | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v Southern Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v Southern Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | Southern Illinois v Youngstown State | W | 30-22 |
Away History
| NCAAF | 2021/09/04 16:00 | Stanford v Kansas State | W | 7-24 |
| NCAAF | 2020/12/05 17:00 | Texas v Kansas State | L | 69-31 |
| NCAAF | 2020/11/29 00:00 | Kansas State v Baylor | L | 31-32 |
| NCAAF | 2020/11/21 21:00 | Kansas State v Iowa State | L | 0-45 |
| NCAAF | 2020/11/07 21:00 | Oklahoma State v Kansas State | L | 20-18 |
| NCAAF | 2020/10/31 16:00 | Kansas State v West Virginia | L | 10-37 |
| NCAAF | 2020/10/24 16:00 | Kansas v Kansas State | W | 14-55 |
| NCAAF | 2020/10/10 20:00 | Kansas State v TCU | W | 21-14 |