Stadium: Tucker Stadium Round: 1
Home Manager: Dewayne Alexander Away Manager: Tom Matukewicz
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri State | W | 21-24 |
| NCAAF | 2019/10/05 23:00 | Tennessee Tech v SE Missouri State | W | 37-43 |
| NCAAF | 2018/10/06 23:00 | SE Missouri State v Tennessee Tech | W | 70-38 |
| NCAAF | 2017/10/14 18:00 | SE Missouri State v Tennessee Tech | W | 31-3 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri State | W | 14-47 |
| NCAAF | 2021/09/18 16:00 | SE Missouri State v Missouri | L | 28-59 |
| NCAAF | 2021/09/11 23:00 | SE Missouri State v Sam Houston State | L | 14-52 |
| NCAAF | 2021/09/02 23:30 | Southern Illinois v SE Missouri State | L | 47-21 |
| NCAAF | 2021/04/11 19:30 | SE Missouri State v Tennessee State | W | 46-23 |
| NCAAF | 2021/04/03 18:00 | SE Missouri State v UT Martin | W | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri State | W | 21-24 |
| NCAAF | 2021/03/21 19:00 | SE Missouri State v Jacksonville State | L | 3-21 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | L | 28-14 |
| NCAAF | 2021/09/18 16:00 | Tennessee Tech v Tennessee | L | 0-56 |
| NCAAF | 2021/09/11 18:30 | Furman v Tennessee Tech | L | 26-0 |
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | L | 14-52 |
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v UT Martin | L | 7-40 |
| NCAAF | 2021/04/03 18:30 | Tennessee State v Tennessee Tech | W | 10-24 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri State | L | 21-24 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | L | 20-28 |