Stadium: Cajun Field Round: 1
Home Manager: Billy Napier Away Manager: Clarence McKinney
| NCAAF | 2019/09/07 23:00 | Texas Southern v Incarnate Word | L | 44-63 |
| NCAAF | 2019/08/31 22:30 | Prairie View A&M v Texas Southern | L | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern v Prairie View A&M | L | 14-60 |
| NCAAF FCS | 2018/11/18 01:30 | Arkansas-Pine Bluff v Texas Southern | L | 15-10 |
| NCAAF FCS | 2018/11/03 19:00 | Texas Southern v Alabama State | L | 21-30 |
| NCAAF | 2018/10/27 19:00 | Texas Southern v Mississippi Valley | W | 42-14 |
| NCAAF | 2018/10/20 19:00 | Texas Southern v Southern | L | 7-21 |
| NCAAF | 2018/10/13 23:00 | Grambling State v Texas Southern | L | 34-21 |
| NCAAF | 2019/09/14 16:30 | Sacred Heart Pion. v Lafayette | L | 56-40 |
| NCAAF | 2019/09/07 23:30 | Liberty v Lafayette | W | 14-35 |
| NCAAF | 2019/09/07 17:00 | Lafayette v Monmouth | L | 21-24 |
| NCAAF | 2019/08/31 22:00 | Lafayette v William & Mary | L | 17-30 |
| NCAAF | 2019/08/31 16:00 | Mississippi State v Lafayette | L | 38-28 |
| NCAAF | 2018/12/15 18:30 | Tulane v Lafayette | L | 41-24 |
| NCAAF | 2018/12/01 17:00 | Lafayette v Appalachian State | L | 19-30 |
| NCAAF | 2018/11/24 20:00 | Lafayette v Louisiana-Monroe | W | 31-28 |