Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Nick Hill
| NCAAF | 2018/09/29 23:00 | South Dakota v Southern Illinois | L | 31-24 |
| NCAAF | 2017/10/28 20:00 | South Dakota v Southern Illinois | L | 42-0 |
| NCAAF | 2019/10/19 19:00 | Youngstown State v Southern Illinois | W | 10-35 |
| NCAAF | 2019/10/12 23:00 | Illinois State v Southern Illinois | L | 21-7 |
| NCAAF | 2019/10/05 19:00 | Southern Illinois v South Dakota State | L | 10-28 |
| NCAAF | 2019/09/21 23:00 | Southern Illinois v Arkansas State | L | 28-41 |
| NCAAF | 2019/09/14 23:00 | UT Martin v Southern Illinois | W | 14-28 |
| NCAAF | 2019/09/07 19:30 | Southern Illinois v Massachusetts | W | 45-20 |
| NCAAF | 2019/08/29 23:30 | Southern Illinois v SE Missouri State | L | 26-44 |
| NCAAF FCS | 2018/11/17 20:30 | Southern Illinois v DAKOTA DU NORD ETAT DU BISON | L | 17-65 |
| NCAAF | 2019/10/19 21:00 | South Dakota v Northern Iowa | L | 27-42 |
| NCAAF | 2019/10/12 19:00 | South Dakota v Missouri State | W | 45-10 |
| NCAAF | 2019/10/05 19:00 | Indiana State v South Dakota | W | 0-38 |
| NCAAF | 2019/09/21 20:00 | South Dakota v Northern Colorado | W | 14-6 |
| NCAAF | 2019/09/14 19:00 | Houston Baptist v South Dakota | L | 53-52 |
| NCAAF | 2019/09/07 23:00 | South Dakota v Oklahoma | L | 14-70 |
| NCAAF | 2019/08/31 19:00 | Montana v South Dakota | L | 31-17 |
| NCAAF FCS | 2018/11/17 20:00 | South Dakota v South Dakota State | L | 27-49 |