Face à face
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL pré-saison | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| NFL pré-saison | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| NFL pré-saison | 2019/08/16 23:00 | BUF Bills v Carolina | W | 27-14 |
| NFL pré-saison | 2019/08/08 23:00 | Indianapolis v BUF Bills | W | 16-24 |
| NFL | 2018/12/30 18:00 | MIA Dolphins v BUF Bills | W | 17-42 |
| NFL | 2018/12/23 18:00 | BUF Bills v Nouvelle-Angleterre | L | 12-24 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL | 2018/12/09 18:00 | NY Jets v BUF Bills | L | 27-23 |
| NFL | 2018/12/02 18:00 | BUF Bills v MIA Dolphins | L | 17-21 |
| NFL | 2018/11/25 18:00 | Jacksonville v BUF Bills | W | 21-24 |
Away History
| NFL pré-saison | 2019/08/18 00:00 | DET Lions v HOU Texans | L | 23-30 |
| NFL pré-saison | 2019/08/08 23:30 | Nouvelle-Angleterre v DET Lions | L | 31-3 |
| NFL | 2018/12/30 18:00 | DET Lions v GB Packers | W | 31-0 |
| NFL | 2018/12/23 18:00 | Minnesota v DET Lions | L | 27-9 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | L | 13-14 |
| NFL | 2018/12/09 21:25 | DET Lions v Arizona | W | 17-3 |
| NFL | 2018/12/02 18:00 | LA Rams v DET Lions | L | 30-16 |
| NFL | 2018/11/22 17:30 | Chicago v DET Lions | L | 23-16 |