Stadium: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Frank Scelfo
| NCAAF FCS | 2018/11/03 19:30 | McNeese State v SE Louisiana | W | 6-23 |
| NCAAF | 2018/10/27 18:00 | Sam Houston State v SE Louisiana | L | 28-25 |
| NCAAF | 2018/10/21 00:00 | SE Louisiana v Abilene Christian | L | 27-48 |
| NCAAF | 2018/10/13 21:00 | Houston Baptist v SE Louisiana | W | 52-62 |
| NCAAF | 2018/10/06 21:00 | SE Louisiana v Incarnate Word | L | 34-52 |
| NCAAF | 2018/09/30 00:00 | Northwestern State v SE Louisiana | W | 17-24 |
| NCAAF | 2018/09/22 23:00 | SE Louisiana v Lamar | W | 30-24 |
| NCAAF | 2018/09/16 00:00 | Central Arkansas v SE Louisiana | L | 33-25 |
| NCAAF FCS | 2018/11/10 21:00 | Stephen F. Austin v Nicholls State | W | 14-47 |
| NCAAF FCS | 2018/11/03 19:00 | Nicholls State v Houston Baptist | W | 41-20 |
| NCAAF | 2018/10/27 20:00 | Nicholls State v Incarnate Word | W | 48-21 |
| NCAAF | 2018/10/13 19:30 | Nicholls State v Abilene Christian | L | 12-28 |
| NCAAF | 2018/10/06 23:00 | Nicholls State v Northwestern State | W | 28-10 |
| NCAAF | 2018/09/29 19:30 | Lamar v Nicholls State | W | 27-50 |
| NCAAF | 2018/09/22 20:00 | Sam Houston State v Nicholls State | W | 7-27 |
| NCAAF | 2018/09/15 23:00 | Nicholls State v McNeese State | L | 10-20 |