| WTA - Indian Wells | 02/26 20:05 | 24 | [179] Di Lorenzo, Francesca v Nao Hibino [118] | 4-6,7-5,6-3 | |
| Rancho Santa Fe, Ca, Singles W-ITF-USA-05A | 02/19 20:55 | 25 | [179] Di Lorenzo, Francesca v Nadia Podoroska [267] | 6-7,1-6 | |
| Midland, Simples W-ITF-USA-03A | 01/31 17:00 | 26 | [162] Di Lorenzo, Francesca v Jessica Pegula [104] | 1-6,4-6 | |
| Midland, Simples W-ITF-USA-03A | 01/31 00:00 | 25 | [162] Di Lorenzo, Francesca v Lauren Davis [202] | 6-3,6-4 | |
| Newport Beach, USA | 01/22 23:15 | 25 | [167] Di Lorenzo, Francesca v Jessica Pegula [113] | 1-6,2-6 | |
| Newport Beach, USA | 01/21 21:05 | 24 | [167] Di Lorenzo, Francesca v Jia-Jing Lu [189] | 6-3,6-4 | |
| WTA Chicago | 09/05 17:40 | 25 | [100] Anna Blinkova v Di Lorenzo, Francesca [193] | 6-4,6-3 | |
| US Open Women | 08/30 18:05 | 24 | [13] Bertens, Kiki v Di Lorenzo, Francesca [193] | 6-2,6-1 | |
| US Open Women | 08/28 17:35 | 23 | [193] Di Lorenzo, Francesca v Mchale, Christina [97] | 6-1,7-6 | |
| US Open Women | 08/24 15:00 | 46 | [111] Mona Barthel v Di Lorenzo, Francesca [193] | 4-6,2-6 | |
| US Open Women | 08/23 15:00 | 45 | [193] Di Lorenzo, Francesca v Lottner, Antonia [151] | 6-4,7-5 | |
| US Open Women | 08/21 17:05 | 44 | [150] Cepede Royg, Veronica v Di Lorenzo, Francesca [193] | 4-6,6-7 | |
| WTA Cincinnati Qual | 08/12 02:45 | 44 | [194] Di Lorenzo, Francesca v Sofia Kenin [68] | 3-6,3-6 | |
| ITF Women Landisville | 08/09 14:00 | 26 | [194] Di Lorenzo, Francesca v Anhelina Kalinina [139] | 3-6,2-6 | |
| ITF Women Landisville | 08/07 15:25 | 25 | [194] Di Lorenzo, Francesca v Jamie Loeb [166] | 6-2,6-3 | |
| Washington, USA, Qualifying | 07/28 17:25 | 64 | [379] Guarachi Mathison, Alexa v Di Lorenzo, Francesca [194] | 2-6,7-5,7-5 | |
| Washington, USA, Qualifying | 07/28 17:20 | - | McNally, Caty v Di Lorenzo, Francesca | Cancelled | |
| ITF Women Granby | 07/25 14:00 | 26 | [194] Di Lorenzo, Francesca v Usue Maitane Arconada [294] | 2-6,2-6 | |
| ITF Women Granby | 07/24 14:00 | 25 | [194] Di Lorenzo, Francesca v Freya Christie [341] | 6-4,0-6,6-3 | |
| ITF Women Berkeley | 07/20 19:00 | 27 | [113] Nao Hibino v Di Lorenzo, Francesca [196] | 7-6,6-1 | |
| ITF Women Berkeley | 07/19 21:05 | 26 | [395] Bai, Alison v Di Lorenzo, Francesca [196] | 4-6,3-6 | |
| ITF Women Berkeley | 07/19 00:00 | 25 | [297] Arconada, Usue Maitane v Di Lorenzo, Francesca [196] | 3-6,5-7 | |
| Wimbledon Women Qual | 06/26 10:00 | 44 | [180] Jing-Jing Lu v Di Lorenzo, Francesca [187] | 6-2,6-3 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/13 09:35 | 26 | [126] Anhelina Kalinina v Di Lorenzo, Francesca [171] | 6-4,6-2 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/12 10:55 | 25 | [171] Di Lorenzo, Francesca v Karatantcheva, Sesil [191] | 6-3,6-0 | |
| ITF Women Brescia | 06/09 12:00 | 28 | [185] Martina Trevisan v Di Lorenzo, Francesca [188] | 6-4,6-2 | |
| ITF Women Brescia | 06/08 13:10 | 27 | [188] Di Lorenzo, Francesca v Dulgheru, Alexandra [159] | 6-7,6-2,7-6 | |
| ITF Women Brescia | 06/07 13:50 | 26 | Di Lorenzo, Francesca v Anne Schaefer | 4-6,7-6,6-0 | |
| ITF Women Brescia | 06/06 09:30 | 25 | [188] Di Lorenzo, Francesca v Piter, Katarzyna [371] | 7-5,6-1 | |
| ITF Women Grado | 05/30 16:30 | 26 | Maria Camila Osorio Serrano v Di Lorenzo, Francesca | 6-3,6-4 |