| ITF Women Montreux | 09/08 13:45 | 28 | [120] Duque Marino, Mariana v Iga Swiatek [298] | 2-6,3-6 | |
| ITF Women Montreux | 09/07 16:30 | 27 | [120] Duque Marino, Mariana v Sadikovic, Amra [235] | 6-7,6-2,7-5 | |
| ITF Women Montreux | 09/06 14:30 | 26 | Duque Marino, Mariana v Stephanie Wagner | 1-6,6-1,6-2 | |
| ITF Women Montreux | 09/05 11:05 | 25 | [120] Duque Marino, Mariana v Scholl, Chiara [271] | 6-1,6-1 | |
| US Open Women | 08/21 19:30 | 44 | [121] Duque Marino, Mariana v Arina Rodionova [152] | 5-7,5-7 | |
| WTA Bucharest | 07/16 11:00 | 25 | [105] Duque Marino, Mariana v Arantxa Rus [111] | 2-6,4-6 | |
| ITF Women Budapest | 07/11 14:30 | 25 | [343] Dalma Galfi v Duque Marino, Mariana [96] | 5-7,7-5,6-4 | |
| Wimbledon Women | 07/03 16:10 | 23 | [60] Alison Riske v Duque Marino, Mariana [96] | 6-1,6-1 | |
| Wimbledon Women Qual | 06/28 11:40 | 46 | [97] Duque Marino, Mariana v Bouchard, Eugenie [191] | 3-6,2-6 | |
| Wimbledon Women Qual | 06/27 11:15 | 45 | [97] Duque Marino, Mariana v Hogenkamp, Richel [160] | 6-4,6-1 | |
| Wimbledon Women Qual | 06/26 10:00 | 44 | [97] Duque Marino, Mariana v Renata Zarazua [192] | 6-4,6-0 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/16 08:00 | 29 | [112] Duque Marino, Mariana v Irina Maria Bara [167] | 4-6,7-5,6-2 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/15 09:00 | 28 | [112] Duque Marino, Mariana v Cagla Buyukakcay [192] | 6-4,6-0 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/14 08:00 | 27 | [112] Duque Marino, Mariana v Ivakhnenko, Valentyna [177] | 6-4,6-2 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/13 08:00 | 26 | [112] Duque Marino, Mariana v Zaja, Anna [247] | 6-2,6-2 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/12 13:25 | 25 | Duque Marino, Mariana v Draginja Vukovic | 6-4,6-4 | |
| Hodmezovasarhely, Simples W-WITF-HUN-06A | 06/12 13:25 | 25 | Duque Marino, Mariana v Kucova, Kristina | Cancelled | |
| WTA Bol | 06/08 14:35 | 27 | [318] Tena Lukas v Duque Marino, Mariana [112] | 6-4,4-6,6-1 | |
| WTA Bol | 06/07 13:00 | 26 | [286] Minella, Mandy v Duque Marino, Mariana [112] | 3-6,1-6 | |
| WTA Bol | 06/06 11:00 | 25 | [150] Tereza Martincova v Duque Marino, Mariana [112] | 6-2,3-6,2-6 | |
| French Open Women | 05/30 16:30 | 24 | [112] Duque Marino, Mariana v Camila Giorgi [57] | 0-6,3-6 | |
| French Open Women | 05/28 11:10 | 23 | [20] Anastasija Sevastova v Duque Marino, Mariana [113] | 6-4,1-6,3-6 | |
| French Open Women Qual | 05/25 09:25 | 46 | [113] Duque Marino, Mariana v Dalila Jakupovic [121] | 4-6,6-1,7-5 | |
| French Open Women Qual | 05/24 10:25 | 45 | [113] Duque Marino, Mariana v Taylor, Gabriella [184] | 6-4,6-4 | |
| French Open Women Qual | 05/23 08:00 | 44 | [113] Duque Marino, Mariana v Katie Boulter [166] | 7-6,7-5 | |
| ITF Women Charleston | 05/03 14:00 | 26 | [95] Duque Marino, Mariana v Iga Swiatek [412] | 4-6,2-6 | |
| ITF Women Charleston | 05/02 14:00 | 25 | [95] Duque Marino, Mariana v Di Lorenzo, Francesca [194] | 6-3,6-1 | |
| ITF Women Charlottesville | 04/29 16:00 | 29 | [151] Anhelina Kalinina v Duque Marino, Mariana [112] | 6-0,1-6,2-6 | |
| ITF Women Charlottesville | 04/28 15:40 | 28 | [112] Duque Marino, Mariana v Brady, Jennifer [85] | 6-4,6-2 | |
| ITF Women Charlottesville | 04/27 16:00 | 27 | [220] Grace Min v Duque Marino, Mariana [112] | 4-6,1-6 |