[2] Club América 2-2 Santos Laguna [4] 2018-05-14 00:00
Weather: Good Stadium: Stade Azteca Pitch: Good Round: 2
Referee: Jorge Perez Home Manager: Miguel Herrera Away Manager: Robert Siboldi
Face à face
| Mexique - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | L | 4-1 |
| Mexique - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | W | 1-0 |
| Mexique - Liga MX | 2017/11/20 00:30 | Santos Laguna v Club América | W | 0-1 |
| Europe - Matchs amicaux | 2017/07/06 01:30 | Club América v Santos Laguna | W | 3-2 |
| Mexique - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club América | L | 2-1 |
| Copa MX, Knockout stage | 2017/03/02 02:30 | Santos Laguna v Club América | L | 2-1 |
| Copa MX, Knockout stage | 2017/01/19 02:30 | Club América v Santos Laguna | W | 3-2 |
| Mexique - Liga MX | 2016/10/30 02:00 | Club América v Santos Laguna | W | 3-1 |
| Coupe des champions CONCACAF | 2016/04/06 02:00 | Club América v Santos Laguna | W | 1-0 |
| Coupe des champions CONCACAF | 2016/03/17 02:00 | Santos Laguna v Club América | D | 0-0 |
| Mexique - Liga MX | 2016/02/06 23:00 | Club América v Santos Laguna | W | 2-0 |
| Mexique - Liga MX | 2015/08/15 02:30 | Santos Laguna v Club América | W | 0-2 |
| Mexique - Liga MX | 2015/03/14 23:00 | Club América v Santos Laguna | W | 1-0 |
| Mexique - Liga MX | 2014/09/27 02:30 | Santos Laguna v Club América | W | 1-4 |
| Mexique - Liga MX | 2014/05/04 02:00 | Santos Laguna v Club América | L | 3-1 |
| Mexique - Liga MX | 2014/05/01 01:00 | Club América v Santos Laguna | W | 5-3 |