[7] Guairena 1-2 River Plate [2] 2021-07-25 21:15
Stadium: Estadio Parque del Guaira Round: 2
Referee: Juan Gabriel Benitez Home Manager: Troadio Daniel Duarte Away Manager: Celso Ayala
Face à face
| Paraguay - Division Profesional | 2021/05/10 00:00 | Guairena v River Plate | D | 0-0 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate v Guairena | L | 4-2 |
| Copa Sudamericana | 2021/03/18 22:15 | Guairena v River Plate | L | 1-2 |
| Paraguay - Division Profesional | 2021/03/05 21:15 | River Plate v Guairena | W | 0-1 |
| Paraguay - Division Profesional | 2020/11/10 23:45 | River Plate v Guairena | W | 1-2 |
| Paraguay - Division Profesional | 2020/08/12 20:00 | River Plate v Guairena | L | 2-1 |
| Paraguay - Division Profesional | 2020/01/25 21:00 | Guairena v River Plate | W | 2-0 |
| Division intermédiaire | 2018/07/29 13:30 | Guairena v River Plate | W | 3-0 |
| Division intermédiaire | 2018/04/21 13:30 | River Plate v Guairena | L | 3-1 |
| Division intermédiaire | 2017/06/24 14:00 | River Plate v Guairena | D | 1-1 |
| Division intermédiaire | 2017/03/19 19:30 | Guairena v River Plate | W | 1-0 |