[4] Penarol 2-1 Olimpia Asuncion [3] 2022-04-13 00:30
Stadium: Stade Campeon del Siglo Round: 2
Referee: Raphael Claus Home Manager: Jose Mauricio Larriera Away Manager: Julio Cáceres
Home History
| Uruguay - Tournoi d'ouverture | 2022/04/09 19:00 | Penarol v Liverpool Montevideo | W | 2-1 |
| Copa Libertadores | 2022/04/05 22:15 | Colón v Penarol | L | 2-1 |
| Uruguay - Tournoi d'ouverture | 2022/04/01 23:00 | Rentistas v Penarol | D | 0-0 |
| Uruguay - Tournoi d'ouverture | 2022/03/19 21:00 | Penarol v Deportivo Maldonado | D | 1-1 |
| Uruguay - Tournoi d'ouverture | 2022/03/05 19:30 | Danubio v Penarol | W | 0-1 |
| Uruguay - Tournoi d'ouverture | 2022/02/27 20:00 | Penarol v Club Nacional de Footbal | W | 1-0 |
| Uruguay - Tournoi d'ouverture | 2022/02/19 23:00 | Albion FC v Penarol | D | 1-1 |
| Uruguay - Tournoi d'ouverture | 2022/02/13 23:00 | Penarol v Defensor Sporting | L | 0-1 |
Away History
| Paraguay - Division Profesional | 2022/04/09 00:15 | Olimpia Asuncion v Club Nacional Asuncion | L | 1-2 |
| Copa Libertadores | 2022/04/05 22:15 | Olimpia Asuncion v Cerro Porteno | D | 0-0 |
| Paraguay - Division Profesional | 2022/04/02 00:15 | Resistencia v Olimpia Asuncion | L | 2-1 |
| Paraguay - Division Profesional | 2022/03/26 21:00 | Sol de America v Olimpia Asuncion | W | 0-1 |
| Paraguay - Division Profesional | 2022/03/20 23:15 | Olimpia Asuncion v Sportivo Ameliano | L | 0-2 |
| Copa Libertadores - Qualif. | 2022/03/17 00:30 | Olimpia Asuncion v Fluminense | W | 6-1 |
| Paraguay - Division Profesional | 2022/03/13 21:00 | Cerro Porteno v Olimpia Asuncion | W | 0-2 |
| Copa Libertadores - Qualif. | 2022/03/10 00:30 | Fluminense v Olimpia Asuncion | L | 3-1 |