Face à face
| MLB | 2022/05/10 01:40 | CHI Cubs v SD Padres | W | 6-0 |
| MLB Exhibition | 2022/03/26 20:10 | CHI Cubs v SD Padres | D | 2-2 |
| MLB Exhibition | 2022/03/19 20:05 | SD Padres v CHI Cubs | W | 4-5 |
| MLB | 2021/06/09 20:10 | CHI Cubs v SD Padres | W | 3-1 |
| MLB | 2021/06/09 02:10 | CHI Cubs v SD Padres | W | 7-1 |
| MLB | 2021/06/08 02:10 | CHI Cubs v SD Padres | L | 4-9 |
| MLB | 2021/06/02 18:20 | SD Padres v CHI Cubs | W | 1-6 |
| MLB | 2021/06/02 00:05 | SD Padres v CHI Cubs | W | 3-4 |
Home History
| MLB | 2022/05/10 01:40 | CHI Cubs v SD Padres | W | 6-0 |
| MLB | 2022/05/08 23:08 | LA Dodgers v CHI Cubs | L | 7-1 |
| MLB | 2022/05/07 23:40 | LA Dodgers v CHI Cubs | L | 6-2 |
| MLB | 2022/05/07 17:05 | LA Dodgers v CHI Cubs | L | 7-0 |
| MLB | 2022/05/04 23:40 | CHI White Sox v CHI Cubs | L | 4-3 |
| MLB | 2022/05/03 23:40 | CHI White Sox v CHI Cubs | L | 3-1 |
| MLB | 2022/05/01 18:10 | CHI Cubs v MIL Brewers | W | 2-0 |
| MLB | 2022/04/30 23:10 | CHI Cubs v MIL Brewers | L | 1-9 |
Away History
| MLB | 2022/05/10 01:40 | CHI Cubs v SD Padres | L | 6-0 |
| MLB | 2022/05/08 20:10 | MIA Marlins v SD Padres | W | 2-3 |
| MLB | 2022/05/08 00:40 | MIA Marlins v SD Padres | L | 8-0 |
| MLB | 2022/05/07 01:40 | MIA Marlins v SD Padres | W | 2-3 |
| MLB | 2022/05/06 01:40 | MIA Marlins v SD Padres | W | 1-2 |
| MLB | 2022/05/04 21:10 | SD Padres v CLE Guardians | L | 5-6 |
| MLB | 2022/05/04 17:10 | SD Padres v CLE Guardians | W | 5-4 |
| MLB | 2022/05/01 17:35 | SD Padres v PIT Pirates | W | 5-2 |