[26] Isner, John 6-7,6-7 Opelka, Reilly [23] 2022-02-12 22:00
Stadium: Stadium Round: 28 Ground: Hardcourt indoor
Face à face
| Atlanta, USA | 2019/07/24 23:00 | Isner, John v Opelka, Reilly | 6-7,7-6,6-7 |
| New York, USA | 2019/02/17 00:00 | Isner, John v Opelka, Reilly | 7-6,6-7,6-7 |
| Open d'Australie | 2019/01/14 02:55 | Opelka, Reilly v Isner, John | 7-6,7-6,6-7,7-6 |
Home History
| ATP - Dallas | 2022/02/12 01:00 | Vasek Pospisil v Isner, John | 4-6,4-6 |
| ATP - Dallas | 2022/02/10 01:00 | Anderson, Kevin v Isner, John | 6-7,7-6,6-7 |
| Open d'Australie | 2022/01/18 03:15 | Maxime Cressy v Isner, John | 7-6,7-5,6-7,6-7,6-4 |
| ATP Adelaide 2 | 2022/01/12 04:30 | Thanasi Kokkinakis v Isner, John | 6-7,7-6,7-6 |
| ATP Cup, Playoffs | 2022/01/05 23:00 | Daniel Evans v Isner, John | 6-4,7-6 |
| ATP Cup, Playoffs | 2022/01/03 23:00 | Jan-Lennard Struff v Isner, John | 7-6,4-6,7-5 |
| ATP Cup, Playoffs | 2022/01/01 23:00 | Schnur, Brayden v Isner, John | 1-6,3-6 |
| Coupe Davis | 2021/11/28 19:10 | Isner, John v Daniel Elahi Galan | 3-6,6-3,6-7 |
Away History
| ATP - Dallas | 2022/02/12 02:25 | Adrian Mannarino v Opelka, Reilly | 3-6,4-6 |
| ATP - Dallas | 2022/02/11 01:00 | Stebe, Cedrik-Marcel v Opelka, Reilly | 6-7,6-7 |
| Open d'Australie | 2022/01/21 04:30 | Opelka, Reilly v Denis Shapovalov | 6-7,6-4,3-6,4-6 |
| Open d'Australie | 2022/01/19 01:40 | Opelka, Reilly v Dominik Koepfer | 6-4,6-3,7-6 |
| Open d'Australie | 2022/01/17 07:45 | Opelka, Reilly v Anderson, Kevin | 6-3,6-4,7-6 |
| Sydney, Australia | 2022/01/14 05:15 | Opelka, Reilly v Andy Murray | 7-6,4-6,4-6 |
| Sydney, Australia | 2022/01/13 05:30 | Brandon Nakashima v Opelka, Reilly | 6-7,2-6 |
| Sydney, Australia | 2022/01/12 03:25 | Jordan Thompson v Opelka, Reilly | 3-6,2-6 |