| 1ère Division, Femmes | 2021/04/29 12:00 | ZRK Despina v ZRK Ilinden Vardar | W | 24-21 |
| 1ère Division, Femmes | 2021/10/28 16:00 | ZRK Despina v Pelister | W | 26-17 |
| Coupe de l'EHF - Femmes | 2021/10/24 12:00 | Skara HF - Femmes v ZRK Despina | L | 38-15 |
| Coupe de l'EHF - Femmes | 2021/10/23 14:00 | ZRK Despina v Skara HF - Femmes | L | 10-37 |
| 1ère Division, Femmes | 2021/10/14 16:00 | Kumanovo v ZRK Despina | L | 30-19 |
| 1ère Division, Femmes | 2021/09/30 11:30 | ZRK Despina v ZRK Gevgelija | W | 28-24 |
| Amicales Club, Dames. | 2021/08/21 09:00 | ZRK Bor - Femmes v ZRK Despina | L | 33-16 |
| Amicales Club, Dames. | 2021/08/20 19:00 | ZRK Despina v Vardar Skopje | L | 18-30 |
| Amicales Club, Dames. | 2021/08/20 09:00 | Jagodina - Femmes v ZRK Despina | L | 36-11 |
| 1ère Division, Femmes | 2021/10/24 14:30 | Pelister v ZRK Ilinden Vardar | D | 30-30 |
| 1ère Division, Femmes | 2021/10/20 14:00 | ZRK Feniks Ams Women v ZRK Ilinden Vardar | L | 33-22 |
| 1ère Division, Femmes | 2021/09/30 10:00 | ZRK Ilinden Vardar v Kumanovo | L | 14-53 |
| 1ère Division, Femmes | 2021/04/29 12:00 | ZRK Despina v ZRK Ilinden Vardar | L | 24-21 |
| 1ère Division, Femmes | 2021/04/11 15:00 | Metalurg v ZRK Ilinden Vardar | L | 53-14 |
| 1ère Division, Femmes | 2021/04/01 17:00 | ZRK Ilinden Vardar v RK Sampion Women | L | 28-35 |
| 1ère Division, Femmes | 2020/11/18 15:00 | Zkr Spartak v ZRK Ilinden Vardar | L | 51-26 |
| 1ère Division, Femmes | 2020/09/25 14:00 | RK Sampion Women v ZRK Ilinden Vardar | L | 37-19 |