[7] Cerro Porteno 2-0 Guairena [3] 2021-08-07 23:30
Stadium: Stade Général Pablo Rojas Round: 4
Referee: Jose Mendez Home Manager: Francisco Arce Away Manager: Troadio Daniel Duarte
Face à face
| Paraguay - Division Profesional | 2021/04/25 21:45 | Guairena v Cerro Porteno | W | 0-1 |
| Paraguay - Division Profesional | 2021/02/21 21:30 | Cerro Porteno v Guairena | D | 2-2 |
| Paraguay - Division Profesional | 2020/11/07 21:15 | Guairena v Cerro Porteno | D | 1-1 |
| Paraguay - Division Profesional | 2020/08/26 21:00 | Guairena v Cerro Porteno | W | 1-2 |
| Paraguay - Division Profesional | 2020/02/15 22:15 | Cerro Porteno v Guairena | D | 2-2 |
Home History
| Copa Libertadores - Qualif. | 2021/08/03 22:15 | Fluminense v Cerro Porteno | L | 1-0 |
| Paraguay - Division Profesional | 2021/07/30 23:30 | River Plate v Cerro Porteno | D | 0-0 |
| Coupe du Paraguay | 2021/07/29 19:00 | Club Dr Benjamin Aceval v Cerro Porteno | W | 0-2 |
| Paraguay - Division Profesional | 2021/07/25 23:30 | Cerro Porteno v Libertad Asuncion | D | 1-1 |
| Paraguay - Division Profesional | 2021/07/16 23:00 | Sportivo Luqueno v Cerro Porteno | D | 0-0 |
| Copa Libertadores - Qualif. | 2021/07/13 22:15 | Cerro Porteno v Fluminense | L | 0-2 |
| Paraguay - Division Profesional | 2021/05/29 00:00 | Guarani Asuncion v Cerro Porteno | L | 2-0 |
| Copa Libertadores | 2021/05/26 00:30 | Cerro Porteno v America de Cali | W | 1-0 |
Away History
| Paraguay - Division Profesional | 2021/08/01 23:15 | Olimpia Asuncion v Guairena | W | 0-2 |
| Paraguay - Division Profesional | 2021/07/25 21:15 | Guairena v River Plate | L | 1-2 |
| Paraguay - Division Profesional | 2021/07/18 23:30 | Libertad Asuncion v Guairena | D | 0-0 |
| Paraguay - Division Profesional | 2021/05/28 21:45 | Sol de America v Guairena | D | 0-0 |
| Paraguay - Division Profesional | 2021/05/21 23:00 | Guairena v Guarani Asuncion | D | 0-0 |
| Paraguay - Division Profesional | 2021/05/16 00:00 | 12 de Octubre v Guairena | D | 1-1 |
| Paraguay - Division Profesional | 2021/05/10 00:00 | Guairena v River Plate | D | 0-0 |
| Paraguay - Division Profesional | 2021/04/30 22:00 | Club Nacional Asuncion v Guairena | W | 1-3 |