[4] Estoril 2-2 Santa Clara [18] 2021-11-29 20:15
Stadium: Estadio Antonio Coimbra da Mota Round: 12
Referee: Fabio Melo Home Manager: Bruno Pinheiro Away Manager: Nuno Campos
Home History
| Portugal - Coupe du Portugal | 2021/11/21 11:00 | Serpa v Estoril | W | 0-5 |
| Portugal - Primeira Liga | 2021/11/06 15:30 | Vizela v Estoril | D | 1-1 |
| Portugal - Primeira Liga | 2021/10/30 18:00 | Estoril v Benfica | D | 1-1 |
| Portugal - Primeira Liga | 2021/10/24 19:30 | Portimonense v Estoril | W | 0-2 |
| Portugal - Coupe du Portugal | 2021/10/17 14:00 | Felgueiras 1932 v Estoril | W | 0-1 |
| Portugal - Primeira Liga | 2021/10/03 17:00 | Estoril v Gil Vicente | D | 2-2 |
| Portugal - Primeira Liga | 2021/09/27 20:15 | Boavista v Estoril | D | 1-1 |
| Portugal - Primeira Liga | 2021/09/19 19:30 | Estoril v Sporting | L | 0-1 |
Away History
| Portugal - Coupe du Portugal | 2021/11/20 18:00 | Braga v Santa Clara | L | 6-0 |
| Portugal - Primeira Liga | 2021/11/07 17:00 | Santa Clara v FC Porto | L | 0-3 |
| Portugal - Primeira Liga | 2021/10/31 18:00 | Belenenses v Santa Clara | L | 2-1 |
| Portugal - Coupe de la Ligue | 2021/10/26 18:00 | Santa Clara v FC Porto | W | 3-1 |
| Portugal - Primeira Liga | 2021/10/23 14:30 | Santa Clara v Famalicao | L | 0-2 |
| Portugal - Coupe du Portugal | 2021/10/16 15:00 | UD Leiria v Santa Clara | W | 0-2 |
| Portugal - Primeira Liga | 2021/10/02 14:30 | Vizela v Santa Clara | D | 1-1 |
| Portugal - Primeira Liga | 2021/09/26 17:00 | Santa Clara v Braga | D | 1-1 |