[3] Independiente Santa Fe 0-0 River Plate [2] 2021-05-07 00:00
Stadium: Stade Général Pablo Rojas Round: 3
Referee: Alexis Herrera Home Manager: Harold Rivera Roa Away Manager: Marcelo Gallardo
Face à face
| Copa Libertadores | 2018/05/04 00:30 | Independiente Santa Fe v River Plate | L | 0-1 |
| Copa Libertadores | 2018/04/05 22:15 | River Plate v Independiente Santa Fe | D | 0-0 |
| Recopa Sudamericana | 2016/08/26 00:15 | River Plate v Independiente Santa Fe | L | 2-1 |
Home History
| Colombie - Primera A | 2021/05/02 18:00 | Independiente Santa Fe v Juniors | D | 0-0 |
| Copa Libertadores | 2021/04/29 00:00 | Independiente Santa Fe v Fluminense | L | 1-2 |
| Colombie - Primera A | 2021/04/25 20:30 | Juniors v Independiente Santa Fe | L | 3-1 |
| Copa Libertadores | 2021/04/23 02:00 | Juniors v Independiente Santa Fe | D | 1-1 |
| Colombie - Primera A | 2021/04/18 20:30 | La Equidad v Independiente Santa Fe | W | 1-2 |
| Colombie - Primera A | 2021/04/12 01:00 | Independiente Santa Fe v Millonarios | L | 1-2 |
| Colombie - Primera A | 2021/04/07 01:00 | Alianza Petrolera v Independiente Santa Fe | W | 0-3 |
| Colombie - Primera A | 2021/04/03 00:40 | Independiente Santa Fe v Deportivo Pereira | D | 1-1 |
Away History
| Argentine - Copa de la Liga Profesional | 2021/05/02 19:30 | Banfield v River Plate | L | 1-0 |
| Copa Libertadores | 2021/04/29 00:00 | River Plate v Juniors | W | 2-1 |
| Argentine - Copa de la Liga Profesional | 2021/04/25 21:00 | River Plate v San Lorenzo | L | 1-2 |
| Copa Libertadores | 2021/04/22 22:00 | Fluminense v River Plate | D | 1-1 |
| Argentine - Copa de la Liga Profesional | 2021/04/17 00:30 | Central Cordoba v River Plate | W | 0-5 |
| Argentine - Copa de la Liga Profesional | 2021/04/12 00:00 | River Plate v Colón | W | 3-2 |
| Argentine - Coupe d'Argentine | 2021/04/07 23:30 | Atlético Tucumán v River Plate | W | 1-2 |
| Argentine - Copa de la Liga Profesional | 2021/04/04 00:00 | Arsenal de Sarandi v River Plate | D | 0-0 |