Stadium: Sam M. Vadalabene Center
Home Manager: Paula Buscher Away Manager: Tiffany Sardin
| WNCAAB | 2020/12/19 00:00 | Eastern Illinois Panthers v SIU Edwardsville - Femmes | L | 73-58 |
| WNCAAB | 2020/12/12 19:00 | SIU Edwardsville - Femmes v Kansas City | L | 81-89 |
| WNCAAB | 2020/12/09 20:00 | SIU Edwardsville - Femmes v St Louis College of Pharmacy Women | W | 63-44 |
| WNCAAB | 2020/12/02 23:00 | Arkansas State - Femmes v SIU Edwardsville - Femmes | L | 80-73 |
| WNCAAB | 2020/11/25 18:00 | Purdue Fort Wayne - Femmes v SIU Edwardsville - Femmes | W | 50-66 |
| WNCAAB | 2020/02/29 22:30 | SIU Edwardsville - Femmes v Eastern Illinois Panthers | L | 62-65 |
| WNCAAB | 2020/02/27 23:30 | Tennessee Martin - Femmes v SIU Edwardsville - Femmes | L | 75-58 |
| WNCAAB | 2020/02/22 22:30 | SIU Edwardsville - Femmes v Murray State - Femmes | L | 61-70 |
| WNCAAB | 2020/11/30 20:00 | Chicago State - Femmes v DePaul - Femmes | L | 66-128 |
| WNCAAB | 2020/11/28 19:00 | Chicago State - Femmes v Loyola Chicago - Femmes | L | 57-70 |
| WNCAAB | 2020/03/11 19:00 | Chicago State - Femmes v Kansas City | L | 52-86 |
| WNCAAB | 2020/02/29 19:00 | Chicago State - Femmes v Kansas City | L | 50-85 |
| WNCAAB | 2020/02/22 21:00 | California Baptist - Femmes v Chicago State - Femmes | L | 103-68 |
| WNCAAB | 2020/02/15 20:00 | Chicago State - Femmes v Grand Canyon - Femmes | L | 57-68 |
| WNCAAB | 2020/02/14 01:00 | Cal State Bakersfield - Femmes v Chicago State - Femmes | L | 58-51 |
| WNCAAB | 2020/02/08 18:00 | UT Rio Grande Valley - Femmes v Chicago State - Femmes | L | 77-68 |