[22] Maria Sakkari 3-6,7-6,3-6 Williams, Serena [8] 2020-09-07 16:00
Stadium: Arthur Ashe Stadium Round: 26 Ground: Hardcourt outdoor
Face à face
| New York, USA | 2020/08/26 00:40 | Maria Sakkari v Williams, Serena | 5-7,7-6,6-1 |
| Hopman Cup Women | 2018/12/31 04:30 | Williams, Serena v Maria Sakkari | 7-6,6-2 |
Home History
| US Open Women | 2020/09/05 15:00 | Maria Sakkari v Amanda Anisimova | 6-3,6-1 |
| US Open Women | 2020/09/03 15:00 | Maria Sakkari v Bernarda Pera | 2-6,6-3,6-2 |
| US Open Women | 2020/09/02 01:00 | Maria Sakkari v Voegele, Stefanie | 6-3,3-6,7-5 |
| New York, USA | 2020/08/26 21:00 | Konta, Johanna v Maria Sakkari | 6-4,6-3 |
| New York, USA | 2020/08/26 00:40 | Maria Sakkari v Williams, Serena | 5-7,7-6,6-1 |
| New York, USA | 2020/08/24 18:00 | Maria Sakkari v Yulia Putintseva | 6-4,7-6 |
| New York, USA | 2020/08/22 16:55 | Maria Sakkari v Gauff, Cori | 6-1,6-3 |
| WTA Palermo | 2020/08/03 22:30 | Pliskova, Kristyna v Maria Sakkari | 6-4,6-4 |
Away History
| US Open Women | 2020/09/05 18:10 | Sloane Stephens v Williams, Serena | 6-2,2-6,2-6 |
| US Open Women | 2020/09/03 23:00 | Margarita Betova v Williams, Serena | 2-6,4-6 |
| US Open Women | 2020/09/01 21:05 | Ahn, Kristie v Williams, Serena | 5-7,3-6 |
| New York, USA | 2020/08/26 00:40 | Maria Sakkari v Williams, Serena | 5-7,7-6,6-1 |
| New York, USA | 2020/08/24 17:00 | Arantxa Rus v Williams, Serena | 6-7,6-3,6-7 |
| WTA Lexington | 2020/08/14 19:15 | Williams, Serena v Shelby Rogers | 6-1,4-6,6-7 |
| WTA Lexington | 2020/08/13 16:45 | Williams, Serena v Venus Williams | 3-6,6-3,6-4 |
| WTA Lexington | 2020/08/11 15:00 | Williams, Serena v Bernarda Pera | 4-6,6-4,6-1 |