| Challenger Las Vegas | 10/26 19:30 | 25 | Steve Johnson v Karlovic, Ivo | Cancelled | |
| ATP - Indian Wells | 10/06 18:00 | 19 | [174] Emilio Gomez v Karlovic, Ivo [200] | 6-3,7-6 | |
| ATP - Indian Wells | 10/05 18:00 | 14 | [231] Schnur, Brayden v Karlovic, Ivo [200] | 6-4,6-7,6-7 | |
| US Open, New York, USA | 08/30 16:50 | 23 | [7] Andrey Rublev v Karlovic, Ivo [221] | 6-3,7-6,6-3 | |
| US Open, New York, USA | 08/27 19:25 | 19 | [131] Sugita, Yuichi v Karlovic, Ivo [223] | 3-6,6-7 | |
| US Open, New York, USA | 08/26 23:10 | 15 | [223] Karlovic, Ivo v Hugo Dellien [137] | 7-5,6-7,6-2 | |
| US Open, New York, USA | 08/25 19:50 | 14 | [223] Karlovic, Ivo v Nikola Milojevic [160] | 6-4,7-6 | |
| Washington, USA | 07/31 20:45 | 14 | [203] Karlovic, Ivo v Illya Marchenko [158] | 3-6,7-6,3-6 | |
| ATP - Los Cabos | 07/21 01:40 | 25 | [63] Jordan Thompson v Karlovic, Ivo [200] | 6-4,7-5 | |
| Newport, USA | 07/14 17:05 | 26 | [37] Alexander Bublik v Karlovic, Ivo [210] | 7-6,4-6,6-1 | |
| Newport, USA | 07/13 15:00 | 25 | [210] Karlovic, Ivo v Bernabe Zapata Miralles [120] | 6-7,6-1,6-4 | |
| Wimbledon, London, Great Britain | 06/22 13:05 | 14 | [156] Roman Safiullin v Karlovic, Ivo [190] | 6-3,6-4 | |
| Challenger - Tallahassee | 04/20 17:40 | 25 | [169] Karlovic, Ivo v Fratangelo, Bjorn [221] | 6-7,7-6,6-7 | |
| ATP - Miami | 03/23 15:45 | 19 | [120] Mackenzie McDonald v Karlovic, Ivo [172] | 7-6,6-4 | |
| ATP - Miami | 03/22 15:40 | 14 | [206] Tatsuma Ito v Karlovic, Ivo [172] | 3-6,6-7 | |
| ATP - Delray Beach | 01/10 23:00 | 26 | [293] Quiroz, Roberto v Karlovic, Ivo [148] | 6-2,6-4 | |
| ATP - Delray Beach | 01/08 23:00 | 25 | [148] Karlovic, Ivo v Andujar, Pablo [59] | 6-3,5-7,6-4 | |
| ATP Cologne | 10/10 09:00 | 64 | [131] Karlovic, Ivo v Marc Polmans [122] | 1-6,4-6 | |
| French Open, Paris, France | 09/23 11:20 | 15 | [226] Benjamin Bonzi v Karlovic, Ivo [131] | 6-3,7-6 | |
| French Open, Paris, France | 09/21 13:40 | 14 | [230] Noah Rubin v Karlovic, Ivo [130] | 6-7,4-6 | |
| US Open, New York, USA | 09/01 23:30 | 23 | [126] Karlovic, Ivo v Richard Gasquet [51] | 6-7,6-7,1-6 | |
| Matchplay 120 | 06/12 13:00 | 1 | [276] Aragone, JC v Karlovic, Ivo [124] | 7-6,7-5 | |
| Challenger Calgary | 02/27 19:15 | 26 | [124] Karlovic, Ivo v Geoffrey Blancaneaux [271] | 6-7,4-6 | |
| Challenger Calgary | 02/26 03:00 | 25 | [124] Karlovic, Ivo v King, Evan [427] | 7-6,6-4 | |
| New York, USA | 02/11 17:00 | 25 | [122] Karlovic, Ivo v Jordan Thompson [63] | 3-6,6-7 | |
| ATP Pune | 02/03 10:00 | 25 | [149] Stebe, Cedrik-Marcel v Karlovic, Ivo [121] | 6-3,6-4 | |
| Open d'Australie | 01/23 05:25 | 24 | [10] Gaël Monfils v Karlovic, Ivo [124] | 4-6,7-6,6-4,7-5 | |
| Open d'Australie | 01/21 10:35 | 23 | [124] Karlovic, Ivo v Vasek Pospisil [138] | 7-6,6-4,7-5 | |
| ATP - Doha | 01/04 08:00 | 64 | [105] Jiri Vesely v Karlovic, Ivo [95] | 6-7,6-3,6-2 | |
| Houston, USA | 11/17 19:00 | 29 | [123] Marcos Giron v Karlovic, Ivo [106] | 7-5,6-7,7-6 |